On the Chrome browser click on wrench icon at the top right and then click “Options”.
Go to “Under the Hood” tab. In the Privacy area click on “Content Settings” button.
Similarly click the “Plug-ins” on the left and check the option next to “Do not allow site to run plug-ins”. Click the “Close” button.
Since the plugins include Flash plugins therefore you can’t run Flash content on your browser after disabling it. For example you can’t play YouTube videos after disabling plug-ins.